Scientific Articles - INRAE

Sustainable resistance management

Rémi Pélissier, François Delmotte, Laurent Delière , Julie Ramirez Martinez, Laura Marolleau, Isabelle Mazet, Frédéric Fabre, Anne-Sophie Miclot (2025). Multiple geographic breakdown events of the Rpv1 – Rpv3.1 pyramided resistance in grapevine by Plasmopara viticola. Plant Disease (https://doi.org/10.1101/2025.08.25.672106)

Julie Ramírez Martínez, Anne-Sophie Miclot, Etienne Dvorak, Isabelle D. Mazet, Carole Couture, Laurent Delière, Frédéric Fabre, Ignace Hoarau, Olivier Yobrégat, Marie Foulongne-Oriol, François Delmotte (in prep.). A multivirulent Plasmopara viticola strain from Cilaos on Réunion Island breaks down Rpv1, Rpv3.1 and Rpv10 mediated resistance of grapevine (https://doi.org/10.1101/2025.09.02.673614)

Elisa Peressotti, Sabine Wiedemann-Merdinoglu, François Delmotte, Diana Bellin, Gabriele Di Gaspero, Raffaele Testolin, Didier Merdinoglu, Pere Mestre (2010). Breakdown of resistance to grapevine downy mildew upon limited deployment of a resistant variety. BMC Plant Biol (http://www.biomedcentral.com/1471-2229/10/147)

François Delmotte , Pere Mestre, Christophe Schneider, Hanns-Heinz Kassemeyer, Pál Kozma, Sylvie Richart-Cervera, Mélanie Rouxel, Laurent Delière (2014). Rapid and multiregional adaptation to host partial resistance in a plant pathogenic oomycete: Evidence from European populations of Plasmopara viticola, the causal agent of grapevine downy mildew. Infection, Genetics and Evolution (https://doi.org/10.1016/j.meegid.2013.10.017)

Chloé E. L. Delmas, Yann Dussert, Laurent Delière, Carole Couture, Isabelle D. Mazet, Sylvie Richart Cervera, François Delmotte (2017). Soft selective sweeps in fungicide resistance evolution: recurrent mutations without fitness costs in grapevine downy mildew. Molecular Ecology (https://doi.org/10.1111/mec.14006).

Lisa Heyman, Rebecca Höfle, Anna Kicherer, Oliver Trapp, Essaid Ait Barka, Reinhard Töpfer and Monica Höfte (2021). The Durability of Quantitative Host Resistance and Variability in Pathogen Virulence in the Interaction Between European Grapevine Cultivars and Plasmopara viticola. Frontiers in Agronomy (https://doi.org/10.3389/fagro.2021.684023)

Manon Paineau, Isabelle D. Mazet, Sabine Wiedemann-Merdinoglu, Frédéric Fabre and François Delmotte (2022). The Characterization of Pathotypes in Grapevine Downy Mildew Provides Insights into the Breakdown of Rpv3, Rpv10 and Rpv12 Factors in Grapevines. Phytopathology (https://doi.org/10.1094/PHYTO-11-21-0458-R).

Catarina Gouveia, Rita B. Santos, Selma Zukic, Thorsten Manthey, Rui Malhó, Andreia Figueiredo and Guenther Buchholz (2024). Novel Plasmopara viticola isolate surpasses grapevine Rpv3.1 and Rpv3.2 resistance but not Rpv12. Plant Pathology (https://doi.org/10.1007/s42161-024-01707-y)

Chantal Wingerter, Birgit Eisenmann, Patricia Weber, Ian Dry and Jochen Bogs (2021). Grapevine Rpv3, Rpv10 and Rpv12 mediated defense responses against Plasmopara viticola and the impact of their deployment on fungicide use in viticulture. BMC Plant Biology (https://doi.org/10.1186/s12870-021-03228-7)

Calonnec A., Wiedemann-Merdinoglu S., Delière L., Cartolaro P., Schneider C., Delmotte F. (2013). The reliability of leaf bioassays for predicting disease resistance on fruit : a case study on grapevine resistance to downy and powdery mildew. Plant Pathology (doi : https://doi.org/10.1111/j.1365-3059.2012.02667.x)

Delmas C. E. L., Fabre F., Jolivet J., Mazet I. D., Richart Cervera S., Deliere L., Delmotte F. (2016). Adaptation of a plant pathogen to partial host resistance: selection for greater aggressiveness in grapevine downy mildew. Evolutionary Applications (https://doi.org/10.1111/eva.12368)

Guimier S., Delmotte F., Miclot A.S., Fabre F., Mazet I., Couture C., Schneider C., Delière L. (2019). OSCAR, a national observatory to support the durable deployment of disease-resistant grapevine varieties. XII International Conference on Grapevine Breeding and Genetics (https://doi.org/10.17660/ActaHortic.2019.1248.4)

Marone Fassolo E., Lecchi B., Marciano D., Maddalena G., Toffolatti S. (2022). Pathogen Adaptation to American (Rpv3-1) and Eurasian (Rpv29) Grapevine Loci Conferring Resistance to Downy Mildew. Plants (https://doi.org/10.3390/plants11192619)

Mestre P., Merdinoglu D., Wiedemann-Merdinoglu S., Calonnec A., Delière L., Delmotte F. (2013), Vers une gestion durable de la résistance de la vigne au mildiou. Innovations Agronomiques (https://hal.inrae.fr/hal-02645820v1)

Miclot A.S., Delmotte F., Bourg J., Mazet I.D., Fabre F., Delière L. (2022). Four years of monitoring of disease-resistant grapevine varieties in French vineyards. BIO Web of Conferences 50 (https://doi.org/10.1051/bioconf/20225002008)

Miclot A.S., Guimier S., Delmotte F., Fabre F., Mazet I., Couture C., Delière L. (2019). Gestion durable des résistances en viticulture. Détecter l’apparition de contournements, l’émergence de nouvelles problématiques sanitaires et adapter les systèmes de cultures. Innovations Agronomiques (https://hal.inrae.fr/hal-02885315v1)

Irene Salotti, Federica Bove, Tao Ji and Vittoro Rossi (2022). Information on disease resistance patterns of grape varieties may improve disease management. Frontiers in Plant Science (https://doi.org/10.3389/fpls.2022.1017658)

Varietal innovation

Blanc S., Merdinoglu-Wiedemann S., Dumas V., Mestre Artigues P.-F., Merdinoglu D. (2012). A reference genetic map of Muscadinia rotundifolia and identification of Ren5, a new major locus for resistance to grapevine powdery mildew. Theoretical and Applied Genetics (https://doi.org/10.1007/s00122-012-1942-3)

Blasi P., Blanc S., Merdinoglu-Wiedemann S., Prado E., Rühl E., Mestre P., Merdinoglu D. (2011). Construction of a reference linkage map of Vitis amurensis and genetic mapping of Rpv8, a locus conferring resistance to grapevine downy mildew. Theoretical and Applied Genetics (https://doi.org/10.1007/s00122-011-1565-0)

Bouquet A, 1980 Vitis x Muscadinia hybridization : A new way in grape breeding for disease resistance in France. Proceed. 3^rd Int. Symp. Grape Breeding, Davis (Cal.), pp 42-61.

Foria S., Magris M., Morgante M., Di Gaspero G. ( 2018). The genetic background modulates the intensity of Rpv3-dependent downy mildew resistance in grapevine. Plant Breeding (https://doi.org/10.1111/pbr.12564)

Merdinoglu D., Wiedemann-Merdinoglu .S, Coste P., Dumas V., Haetty S., Butterlin G., Greif C. (2003) Genetic analysis of downy mildew resistance derived from Muscadinia rotundifolia. Acta Horticulturae (https://doi.org/10.17660/ActaHortic.2003.603.57)

Merdinoglu D., Schneider C., Prado E., Wiedemann-Merdinoglu S., Mestre P. (2018) Breeding for durable resistance to downy and powdery mildew in grapevine. Oeno one (https://doi.org/10.20870/oeno-one.2018.52.3.2116)

Pauquet J., Bouquet A., This P., Adam-Blondon A.F. (2001) Establishment of a local map of AFLP markers around the powdery mildew resistance gene Run1 in grapevine and assessment of their usefulness for marker assisted selection. Theoretical and Applied Genetics (https://doi.org/10.1007/s001220100664)

Pessina S., Lenzi L., Perazzolli M., Campa M., Dalla Costa L., Urso S., Valè G., Salamini F., Velasco R., Malnoy M.(2016). Knockdown of MLO genes reduces susceptibility to powdery mildew in grapevine. Horticulture Research (https://doi.org/10.1038/hortres.2016.16)

Schneider C., Onimus C., Prado E., Dumas V., Wiedemann-Merdinoglu S., Dorne, M.A., Lacombe M.C., Piron M.C., Umar-Faruk A., Duchêne E., Mestre P., Merdinoglu D. (2019). INRA-ResDur: the French grapevine breeding programme for durable resistance to downy and powdery mildew. Acta Horticulturae (https://doi.org/10.17660/ActaHortic.2019.1248.30)

Schneider C, Spring J.L, Onimus C., Prado E., Verdenal T., Lemarquis G., Lorenzini F., Ley L., Duruz P., Gindro K., Merdinoglu D. (2019). Programme de collaboration franco-suisse pour la création de nouvelles variétés de vigne durablement résistantes au mildiou et à l’oïdium. BIO Web of Conferences 15, 01018. 42nd World Congress of Vine and Wine (https://doi.org/10.1051/bioconf/20191501018)

Schwander F., Eibach R., Fechter I., Hausmann L., Zyprian E., Töpfer R. (2012). Rpv10: a new locus from the Asian Vitis gene pool for pyramiding downy mildew resistance loci in grapevine. Theoretical and Applied Genetics (https://doi.org/10.1007/s00122-011-1695-4)

Venuti S., Copetti D., Foria S., Faliginella L., Hoffmann S., Bellin D., Cindric P., Kozma P., Scalabrin S., Morgante M., Testolin R., Di Gaspero G. (2013). Historical Introgression of the Downy Mildew Resistance Gene Rpv12 from the Asian Species Vitis amurensis into Grapevine Varieties. Plos One (https://doi.org/10.1371/journal.pone.0061228)

Vezzulli S., Vecchione A., Stefanini M., Zulini L. (2018). Downy mildew resistance evaluation in 28 grapevine hybrids promising for breeding programs in Trentino region (Italy). European Journal of Plant Pathology (https://doi.org/10.1007/s10658-017-1298-2)

Viret O., Spring J.L., Gindro K. (2018). Stilbenes: biomarkers of grapevine resistance to fungal diseases. Oeno one (https://doi.org/10.20870/oeno-one.2018.52.3.2033)

Yin Xiao, Liu Rui-Qi, Su Hang, Su Li, Guo Yu-Rui, Wang Zi-Jia, Du Wei, Li Mei-Jie, Zhang Xi, Wang Yue-Jin, Liu Guo Tian, Xu Yan. (2017). Pathogen development and host responses to Plasmopara viticola in resistant and susceptible grapevines: An ultrastructural study. Horticulture Research (https://doi.org/10.1038/hortres.2017.33)

Yobregat O. (2018). Introduction to resistant vine types : a brief history and overview of the situation. Oeno one (https://doi.org/10.20870/oeno-one.2018.52.3.2220)

Zini E., Dolzani C., Stefanini M., Gratl V., Bettinelli P., Nicolini D., Betta G., Dorigatti C., Velasco R., Letschka T., Vezzulli S. (2019). R-Loci Arrangement Versus Downy and Powdery Mildew Resistance Level : A Vitis Hybrid Survey. International Journal of Molecular Sciences (https://doi.org/10.3390/ijms20143526)

Socio-economic studies

De la Fuentes Lloreda M. (2018). Use of hybrids in viticulture. A challenge for the OIV. Oeno One (https://doi.org/10.20870/oeno-one.2018.52.3.2312)

Fuentes Espinoza A., Hubert A., Raineau Y., Franc C., Giraud-Héraud E. (2018). Resistant grape varieties and market acceptance: an evaluation based on experimental economics. Oeno One (doi.org/10.20870/oeno-one.2018.52.3.2316)

Fuller K.B., Alston J.M., Sambucci O.S. (2014). The value of powdery mildew resistance in grapes: Evidence from California. Wine Economics and Policy (https://doi.org/10.1016/j.wep.2014.09.001)

Montaigne E., Coelho A., Khefifi L. (2016). Economic issues and perspectives on innovation in new resistant grapevine varieties in France. Wine Economics and Policy (https://doi.org/10.1016/j.wep.2016.11.002)

Pedneault K., Provost C. (2016). Fungus resistant grape varieties as a suitable alternative for organic wine production: Benefits, limits, and challenges. Scientia Horticulturae (https://doi.org/10.1016/j.scienta.2016.03.016)

Montaigne E. (2021). A comprehensive economic examination and prospects on innovation in new grapevine varieties dealing with global warming and fungal diseases. Sustainability (https://doi.org/10.3390/su132313254)

Oenology

Salmon J.M., Ojeda H., Escudier J.L. (2018). Disease resistant grapevine varieties and quality: the case of Bouquet varieties. Oeno One (https://doi.org/10.20870/oeno-one.2018.52.3.2139)

Tessedre J.L. (2018). Composition of grape and wine from resistant vines varieties. Oeno One (https://doi.org/10.20870/oeno-one.2018.52.3.2223)

Reyes González-Centeno M. (2019). Disease resistant Bouquet vine varieties: assessment of the phenolic, aromatic, and sensory potential of their wines. Biomolecules (https://doi.org/10.3390/biom9120793)

Frioni T. (2021). Investigating evolution and balance of grape sugars and organic acids in some new pathogen-resistant white grapevine varieties. Horticulturae (https://doi.org/10.3390/horticulturae7080229)